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Molecular Design and Bioorganic Catalysis by Wilcox NATO 2013 Hardcover FAST A66

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Educational Level
Adult & Further Education
Level
Advanced
ISBN
9780792340249
EAN
9780792340249

關於產品

Product Identifiers

Publisher
Springer Netherlands
ISBN-10
0792340248
ISBN-13
9780792340249
eBay Product ID (ePID)
645821

Product Key Features

Number of Pages
Xvi, 268 Pages
Language
English
Publication Name
Molecular Design and Bioorganic Catalysis
Subject
Life Sciences / Biochemistry, Pharmacy, Chemistry / Organic, Chemistry / General
Publication Year
1996
Type
Textbook
Subject Area
Science, Medical
Author
Andrew D. Hamilton
Series
NATO Science Series C: Ser.
Format
Hardcover

Dimensions

Item Weight
45.5 Oz
Item Length
9.2 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Scholarly & Professional
LCCN
96-011980
Dewey Edition
20
Series Volume Number
478
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
574.19/24
Table Of Content
The Site of Cleavage of Pyranoside Acetals: Endo vs. Exocyclic Cleavage.- Vitamin K Mechanism of Action and Its Bearing on Vitamin E.- Unnatural Amino Acids for the Design of Functional Proteins: Biomimetic Catalysis Using Coenzyme-Amino Acids.- Nonconventional Approaches to Enzyme-Catalyzed Peptide Synthesis.- Alkaline-Earth Metal Ion Catalysis of Ester Cleavage.- A Study of the Catalytic Properties of Some Hydrogen Bonding Receptors.- Design, Synthesis, and Study of Artificial ?-Sheets.- Anion Recognition by Neutral Receptors.- Enzymes in the Continuous Gas Phase Bioreactor.- Foldable Anion Hosts Based on Bicyclic Guanidinium Anchor Groups.- Transition Metal Ion-Based Supramolecular Catalysts.- Neutral Organoboron Receptors with Oriented Dipoles.- Regulation of Protein Synthesis by Antitumor Peptides.- Author Index.
Synopsis
One of the most active areas of contemporary organic chemistry involves the search for new catalysts that borrow concepts, strategies and even components from enzymes but yet are not found in nature. Such artificial enzymes not only give enormous insights into the mechanisms of enzyme catalysis but also offer the potential for catalyzing a wide range of chemical reactions with no counterpart in nature. Several approaches have been taken in the deVelopment of new catalysts, some based on biological methods and others on synthetic techniques. Site directed mutagenesis has allowed the direct replacement of amino acids in an enzyme with resulting changes in stability, selectivity and mechanism. Recent developments have shown that even non-natural amino acids can be incorporated into proteins and also that enzymes can function effectively in organic solvents. A different biological route to artificial enzymes has exploited the immune system and its ability to generate millions of antibodies to a given antigen. Novel antigens have been designed to mimic the transition states of chemical reactions. Antibodies elicited against these antigens thus contain an active site that is complementary to transition state structure and can potentially catalyze target reactions. A broad range of reactions can now be 6 catalyzed using the method with rate accelerations reaching 10 compared to the control reactions. Protein engineering and catalytic antibodies represent complex solutions to the problem of artificial enzymes. Their complexity is however their principal limitation., Proceedings of the NATO Advanced Research Workshop on 'Bioorganic Catalysis', Johnstown, Pennsylvania, U.S.A., May 17-21, 1995
LC Classification Number
QP550-801

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