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ISBN
9781441903211
Publication Year
2009
Type
Textbook
Format
Hardcover
Language
English
Publication Name
Development and Engineering of Dopamine Neurons
Item Height
254mm
Author
Jeroen Pasterkamp, Marten P. Smidt, J. Peter H. Burbach
Publisher
Springer-Verlag New York Inc.
Item Width
178mm
Subject
Medicine
Number of Pages
127 Pages

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Product Information

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Product Identifiers

Publisher
Springer-Verlag New York Inc.
ISBN-13
9781441903211
eBay Product ID (ePID)
89687162

Product Key Features

Author
Jeroen Pasterkamp, Marten P. Smidt, J. Peter H. Burbach
Publication Name
Development and Engineering of Dopamine Neurons
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2009
Type
Textbook
Number of Pages
127 Pages

Dimensions

Item Height
254mm
Item Width
178mm
Volume
561

Additional Product Features

Series Title
Advances in Experimental Medicine and Biology
Country/Region of Manufacture
United States
Editor
Jeroen Pasterkamp, Marten P. Smidt, J. Peter H. Burbach

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