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THERAPEUTIC TARGETS OF THE TNF SUPERFAMILY (ADVANCES IN By Iqbal S. Grewal *NEW*

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ISBN-10
0387895191
Book Title
Therapeutic Targets of the TNF Superfamily (Advances in
Genre
Immunology
Item Height
10.1 inches
ISBN
9780387895192
Subject Area
Medical
Publication Name
Therapeutic Targets of the Tnf Superfamily
Item Length
10 in
Publisher
Springer New York
Subject
Immunology, Oncology, Research, Diseases
Series
Advances in Experimental Medicine and Biology Ser.
Publication Year
2009
Type
Textbook
Format
Hardcover
Language
English
Author
Iqbal S. Grewal
Item Width
7 in
Item Weight
22.6 Oz
Number of Pages
Xvii, 220 Pages

關於產品

Product Information

Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Liga- receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, including activation, proliferation, differentiation, and apoptosis. The particular response depends on the receptor, the cell type, and the concurrent signals received by the cell. Worldwide interest in the TNF field surged dramatically early in 1984 with the cloning and defining of the profound cellular effects of the first member of this family, TNF . Subsequently, the major influence of TNF on the development and functioning of the immune system was established. Today, over 20 human TNF ligands and their more than 30 corresponding receptors have been identified. Few receptors still remain orphans. What has emerged over the years is that most TNF ligands bind to one distinct receptor and some of the TNF ligands are able to bind to multiple TNF receptors, explaining to some extent the apparent disparity in the number of TNF receptors and ligands. Yet, in spite of some redundancy in TNF ligand/receptor interactions, it is clear that in vivo spatial, temporal, and indeed cell- and tissue-specific expression of both ligands and their receptors are important factors in determining the precise nature of cellular, physiological and pathological processes they control. TNF superfamily has been the most highly investigated area of basic medical research for over two decades.

Product Identifiers

Publisher
Springer New York
ISBN-10
0387895191
ISBN-13
9780387895192
eBay Product ID (ePID)
102803564

Product Key Features

Author
Iqbal S. Grewal
Publication Name
Therapeutic Targets of the Tnf Superfamily
Format
Hardcover
Language
English
Subject
Immunology, Oncology, Research, Diseases
Series
Advances in Experimental Medicine and Biology Ser.
Publication Year
2009
Type
Textbook
Subject Area
Medical
Number of Pages
Xvii, 220 Pages

Dimensions

Item Length
10 in
Item Width
7 in
Item Weight
22.6 Oz

Additional Product Features

LCCN
2008-047209
Intended Audience
Scholarly & Professional
Series Volume Number
647
Number of Volumes
1 Vol.
Lc Classification Number
Qr180-189.5
Table of Content
Overview of TNF Superfamily: A Chest Full of Potential Therapeutic Targets.- Therapeutic Interventions Targeting CD40L (CD154) and CD40: The Opportunities and Challenges.- Targeting TNF for Treatment of Cancer and Autoimmunity.- Targeting of BAFF and APRIL for Autoimmunity and Oncology.- The Role of FasL and Fas in Health and Disease.- OX40 (CD134) and OX40L.- Targeting CD70 for Human Therapeutic Use.- 4-1BB as a Therapeutic Target for Human Disease.- RANK(L) as a Key Target for Controlling Bone Loss.- Targeting the LIGHT-HVEM Pathway.- GITR: A Modulator of Immune Response and Inflammation.- Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.- Tumor Necrosis Factor Receptor Superfamily Member 21: TNFR-Related Death Receptor-6, DR6.- TRAIL and Other TRAIL Receptor Agonists as Novel Cancer Therapeutics.- Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Copyright Date
2009
Dewey Decimal
616.07/9
Dewey Edition
22
Illustrated
Yes

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