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Immunological Synapse - 9783642261855

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Book Title
Immunological Synapse
ISBN
9783642261855
Publication Year
2012
Type
Textbook
Format
Paperback
Language
English
Publication Name
Immunological Synapse
Item Height
235mm
Author
Facundo D. Batista, Takashi Saito
Publisher
Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Item Width
155mm
Subject
Medicine
Item Weight
421g
Number of Pages
255 Pages

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Product Information

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide-MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide-MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide- MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

Product Identifiers

Publisher
Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
ISBN-13
9783642261855
eBay Product ID (ePID)
139779470

Product Key Features

Author
Facundo D. Batista, Takashi Saito
Publication Name
Immunological Synapse
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2012
Type
Textbook
Number of Pages
255 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
340
Item Weight
421g

Additional Product Features

Series Title
Current Topics in Microbiology and Immunology
Editor
Facundo D. Batista, Takashi Saito
Country/Region of Manufacture
Germany

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商業賣家資料

增值稅識別編號:
  • GB 976952259
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