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Real-Time Analysis of Biomolecular Interactions: Applications of BIACORE by K. N

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ISBN-13
9784431669722
Book Title
Real-Time Analysis of Biomolecular Interactions
ISBN
9784431669722
Subject Area
Science
Publication Name
Real-Time Analysis of Biomolecular Interactions : Applications of Biacore
Item Length
9.3 in
Publisher
Springer Japan
Subject
Life Sciences / Biochemistry
Publication Year
2012
Type
Textbook
Format
Trade Paperback
Language
English
Author
H. Handa
Item Width
6.1 in
Item Weight
14.9 Oz
Number of Pages
Xi, 256 Pages

關於產品

Product Information

Elaborate and complex interactions among the molecules that make up all living or- ganisms are the basis by which those organisms carry out their existence. All metabo- lism or vital activities of living organisms are attributed to the interactions of numbers of biomolecules, including protein-protein interactions. Cell growth and differentia- tion, development and generation or regeneration of tissue, and the occurrence of or protection against various diseases are triggered, conducted, and maintained by the complex sequential interactions among molecules both inside and outside the cells. Each protein has its own function, but it cannot function by itself. For example, enzymes catalyze reactions only through transient interaction with their substrates. In some cases, proteins carry out their functions only after they form a multi subunit com- plex. GenerallY, proteins, nucleotides, lipids, sugars, and other small molecules func- tion through the interaction of mUltiple molecules either simultaneously or succes- sively. In the case of signal transduction, for example, a ligand first binds to the cell sur- face receptors, the ligand-receptor complex is internalized, signals are transferred one by one through the intracellular signal molecules, and finally the signal reaches the target molecules. In these processes, the signal is mediated mainly by phosphorylation, and this phosphorylation is transduced from upstream to downstream by transient in- teractions of the donors with the acceptors. Phosphorylation and de-phosphorylation themselves are also characterized as transient interactions between phosphates and tar- get proteins.

Product Identifiers

Publisher
Springer Japan
ISBN-10
4431669728
ISBN-13
9784431669722
eBay Product ID (ePID)
175734336

Product Key Features

Author
H. Handa
Publication Name
Real-Time Analysis of Biomolecular Interactions : Applications of Biacore
Format
Trade Paperback
Language
English
Subject
Life Sciences / Biochemistry
Publication Year
2012
Type
Textbook
Subject Area
Science
Number of Pages
Xi, 256 Pages

Dimensions

Item Length
9.3 in
Item Width
6.1 in
Item Weight
14.9 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
Qd415-436
Table of Content
(1) Significance of the Real-Time Analysis of Biological Interactions.- (2) General Principles: Principles of Surface Plasmon Resonance. Principles of BIACORE.- (3) Basic Procedures: Experimental Procedures. Data Analysis Methods.- (4) Applications: Protein-Protein Interactions. Peptid-Protein Interactions. DNA-Protein Interactions. DNA-DNA Interactions. Sugar-Protein Interactions. Lipid-Protein Interactions. Applications for Purification and Screening. Clinical Applications. Combinations with Other Methods.- (5) The View for the Future.
Copyright Date
2000
Target Audience
Scholarly & Professional
Illustrated
Yes

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