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The Genetics of Obesity by Struan F.A. Grant (English) Hardcover Book

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ISBN-13
9781461486411
Book Title
The Genetics of Obesity
ISBN
9781461486411
Subject Area
Science, Medical
Publication Name
Genetics of Obesity
Item Length
9.3 in
Publisher
Springer New York
Subject
Life Sciences / Genetics & Genomics, Endocrinology & Metabolism, Genetics, Research, Bariatrics
Publication Year
2013
Type
Textbook
Format
Hardcover
Language
English
Author
Struan F. A. Grant
Item Width
6.1 in
Item Weight
117 Oz
Number of Pages
VIII, 128 Pages

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Product Information

In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.

Product Identifiers

Publisher
Springer New York
ISBN-10
1461486416
ISBN-13
9781461486411
eBay Product ID (ePID)
169474121

Product Key Features

Author
Struan F. A. Grant
Publication Name
Genetics of Obesity
Format
Hardcover
Language
English
Subject
Life Sciences / Genetics & Genomics, Endocrinology & Metabolism, Genetics, Research, Bariatrics
Publication Year
2013
Type
Textbook
Subject Area
Science, Medical
Number of Pages
VIII, 128 Pages

Dimensions

Item Length
9.3 in
Item Width
6.1 in
Item Weight
117 Oz

Additional Product Features

LCCN
2013-950488
Intended Audience
Scholarly & Professional
Number of Volumes
1 Vol.
Lc Classification Number
Rb155-155.8
Table of Content
Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies.- Genetic Obesity Syndromes.- Genome-Wide Association Studies of Obesity.- Copy Number Variants and their Contribution to the Risk of Obesity.- Genetics of Childhood Obesity.- Genetic Pleiotropies of Obesity.- Functional Follow-up of Genetic Variants Using FTO as the Prime Example.- Index.
Copyright Date
2014
Dewey Decimal
616.3/98042
Dewey Edition
23
Illustrated
Yes

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