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Current Topics in Tumor Cell Physiology and Positron-Emission Tomography by W. K

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ISBN-13
9783540130079
Book Title
Current Topics in Tumor Cell Physiology and Positron-Emission Tom
ISBN
9783540130079
Publication Year
1984
Type
Textbook
Format
Trade Paperback
Language
English
Subject Area
Medical
Publication Name
Current Topics in Tumor Cell Physiology and Positron-Emission Tomography
Author
W. Knapp
Publisher
Springer Berlin / Heidelberg
Subject
Oncology, Physiology
Item Weight
8.3 Oz
Number of Pages
Xii, 104 Pages

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Product Information

About ten years aga devices and equipment were developed for producing quantitative images in vivo of the distribution of substanees with positron- emitting radionuclide label of very short half-life (down to only several minutes). The positron-emitting isotopes can be the most important bio- elements and are, therefore, suitable for the labeling of important physio- logie substrates like sugars, amino acids ete. and their synthetic analogues. Their imaging, after distribution in vivo, is being performed by PET scan- ning systems. It soon became apparent that positron-emission tomography could be very useful in the field of cancer biology, diagnostics and therapy. Trans- port, influx and efflux, metabolism of suitable labeled substrates around and in tumors can be followed over aperiod oftime, thus allowing the - calization oftumors and - equally important - the efficiency (or non-effi- ciency) of any given therapeutic regimen. For this purpose 13N-Iabeled amino acids, especially glutamate, or l1C_ and 18P-labeled glucose deri- vates were introduced and are already being recommended for the study of special tumors in experimental animals and man, such as brain tumors or osteosarcomas. Some glucose derivatives were developed which differ in their metabolie (enzymatic) fate. In this way, combined application of compounds, like 18F]-2-fluoro-2-deoxy- and rtC]-3-0-methyl-D-glucose are "expected to provide the most important imaging in tumor diagno- stics" (M. Hatanaka). In principle, tlJmor chemotherapy and other therapeutic approaches can now be followed continuously.

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
3540130071
ISBN-13
9783540130079
eBay Product ID (ePID)
169607013

Product Key Features

Author
W. Knapp
Publication Name
Current Topics in Tumor Cell Physiology and Positron-Emission Tomography
Format
Trade Paperback
Language
English
Subject
Oncology, Physiology
Publication Year
1984
Type
Textbook
Subject Area
Medical
Number of Pages
Xii, 104 Pages

Dimensions

Item Weight
8.3 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
Rc254-282
Table of Content
Metabolic and Transport Alterations in Cells Transformed by Rous Sarcoma Virus.- Some Tumour Markers in Malignant and Non-Malignant Hybrid Cells.- D-Glucose Transport in Oncogenic Transformation.- In Vivo Determination of Kinetic Parameters for Glucose Influx and Efflux by Means of 3-0-11C-Methyl-D-Glucose, 18F-3-Deoxy-3-Fluoro-D-Glucose and Dynamic Positron Emission Tomography; Theory. Method and Normal Values.- Physiological Conditions and Methodological Prerequists for the In-Vivo Measurement of Substrate Transport in Tumors.- Diagnostic Demands in Clinical and Experimental Oncology: Application of Substrates Labeled with Positron-Emitting Radionuclides.- Labeling of Organic Compounds with Positron Emitters.
Copyright Date
1984
Target Audience
Scholarly & Professional
Illustrated
Yes

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