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Macrolide Antibiotics by H.A. Kirst (English) Paperback Book
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- ISBN-13
- 9783034894388
- Book Title
- Macrolide Antibiotics
- ISBN
- 9783034894388
- Subject Area
- Medical
- Publication Name
- Macrolide Antibiotics
- Publisher
- Springer Basel A&G
- Item Length
- 9.3 in
- Subject
- Immunology, Pharmacology, Diseases
- Publication Year
- 2012
- Series
- Milestones in Drug Therapy Ser.
- Type
- Textbook
- Format
- Trade Paperback
- Language
- English
- Item Weight
- 18.2 Oz
- Item Width
- 6.1 in
- Number of Pages
- X, 323 Pages
關於產品
Product Identifiers
Publisher
Springer Basel A&G
ISBN-10
3034894384
ISBN-13
9783034894388
eBay Product ID (ePID)
176379164
Product Key Features
Number of Pages
X, 323 Pages
Publication Name
Macrolide Antibiotics
Language
English
Publication Year
2012
Subject
Immunology, Pharmacology, Diseases
Type
Textbook
Subject Area
Medical
Series
Milestones in Drug Therapy Ser.
Format
Trade Paperback
Dimensions
Item Weight
18.2 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
Dewey Edition
21
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615/.329
Table Of Content
to the macrolide antibiotics.- Macrolides: a clinical overview.- Pharmacokinetics/pharmacodynamics of macrolides.- Cellular accumulation of macrolide antibiotics. Intracellular bioactivity.- Clarithromycin and new derivatives of erythromycin.- Azithromycin and novel azalides.- Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within gram-positive cocci.- Novel macrolide derivatives active against resistant pathogens.- Polyketide diversity.- Biosynthesis of the macrolide antibiotic, tylosin.- Activity of macrolides against mycobacteria.- Chlamydia pneumoniae and asthma and atherosclerosis: role of macrolides...- Activity of macrolides in sexually transmitted diseases.- Helicobacter pylori and macrolides.- Effects of macrolide antibiotics on ribosome function.- Mechanisms of resistance to macrolides, lincosamides, and ketolides.
Synopsis
There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery- thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy- cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro- lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics., There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro lactone structures, giving historic background, basic structure-activity relation ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
LC Classification Number
RM300-666
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