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Leukocyte Integrins in the Immune System and Malignant Disease by Bernhard Holzm

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ISBN-13
9783642719899
Book Title
Leukocyte Integrins in the Immune System and Malignant Disease
ISBN
9783642719899
Subject Area
Science, Medical
Publication Name
Leukocyte Integrins in the Immune System and Malignant Disease
Item Length
9.3 in
Publisher
Springer Berlin / Heidelberg
Subject
Immunology, Hematology, Life Sciences / Cell Biology, Oncology
Publication Year
2012
Series
Current Topics in Microbiology and Immunology Ser.
Type
Textbook
Format
Trade Paperback
Language
English
Item Height
0.2 in
Author
Hermann Wagner
Item Width
6.1 in
Item Weight
11.2 Oz
Number of Pages
VIII, 189 Pages

關於產品

Product Information

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). Adhesion interactions of vascular endothelium with lymphocytes under flow or shear consist of at least four steps: (I) an initial transient sticking or rolling; (2) if the lymphocytes encounter appropriate activating or chemotactic factors in the local environment, rolling may be followed by a lymphocyte activation step that then leads to; (3) strong adhesion or sticking that may be followed by; (4) lym- phocyte diapedesis into tissue (BUTCHER 1991; SHIMUZU et al. 1992; SPRINGER 1994; BARGATZE et al. 1995). Specific lymphocyte and endothelial adhesion molecules (AM) are involved in each step of this "adhesion cascade" (reviewed in CARLOS and HARLAN 1994; IMHOF and DUNON 1995; BUTCHER and PICKER 1996). This allows lymphocyte migration to be controlled at several different steps, leading to a combinatorial increase in specificity and sensitivity.

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
3642719899
ISBN-13
9783642719899
eBay Product ID (ePID)
143728051

Product Key Features

Author
Hermann Wagner
Publication Name
Leukocyte Integrins in the Immune System and Malignant Disease
Format
Trade Paperback
Language
English
Subject
Immunology, Hematology, Life Sciences / Cell Biology, Oncology
Publication Year
2012
Series
Current Topics in Microbiology and Immunology Ser.
Type
Textbook
Subject Area
Science, Medical
Number of Pages
VIII, 189 Pages

Dimensions

Item Length
9.3 in
Item Height
0.2 in
Item Width
6.1 in
Item Weight
11.2 Oz

Additional Product Features

Intended Audience
Scholarly & Professional
Series Volume Number
231
Number of Volumes
1 Vol.
Lc Classification Number
Qr180-189.5
Table of Content
List of Contents.- VLA-4-Mediated Signaling.- Functions of ?4-?7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development.- Regulation of Integrin Function by Inside-Out Signaling Mechanisms.- The Role of ?4-Integrins in T Lymphocyte Migration Into the Inflamed and Noninflamed Central Nervous System.- The Roles of ?4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus.- Immunosuppression by Blocking ?4-Integrins/VCAM-l Adhesion.- Virus-Induced T Cell Activation and the Inflammatory Response.- ?4 Integrins and Tumor Metastasis.- Organ-Specific Requirements for Cell Adhesion Molecules During Lymphoma Cell Dissemination.- The Ups and Downs of ?2?1-Integrin Expression: Contributions to Epithelial Cell Differentiation and the Malignant Phenotype.
Copyright Date
1998
Illustrated
Yes

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